ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation
J. B. Graham, J. C. Sunryd, K. Mathavan, E. Weir, I. S. B. Larsen, A. Halim, H. Clausen, H. Cousin, D. Alfandari, D. N. Hebert
This study shows TMTC3 enables O-mannosylation of E-cadherin, affecting cell adhesion and gastrulation, and links TMTC3 mutations to Cobblestone lissencephaly.
bioRxiv · Oct 30, 2019Cell Biology