D. Pan

scCancerExplorer: a comprehensive database for interactively exploring single-cell multi-omics data of human pan-cancer

scCancerExplorer provides an interactive database for exploring single-cell multi-omics data across 50 cancer types, integrating genomic, epigenomic, and transcriptomic data.

Condensin II activation by M18BP1

The paper identifies M18BP1 as a factor required for condensin II localization to chromatin and shows it competes with MCPH1 to activate condensin II during mitosis.

Adaptive optical third-harmonic generation microscopy for in vivo imaging of tissues

This paper introduces an adaptive optical third-harmonic generation microscope that improves in vivo imaging by correcting optical aberrations in complex tissues.

Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy

This study uses third-harmonic generation microscopy to image plant roots and microbes in their natural environment without labels.

Role of PLK1 in the epigenetic maintenance of centromeres

The paper identifies a phosphorylation network regulated by PLK1 that controls a conformational switch necessary for CENP-A deposition, essential for centromere maintenance.

VHL loss enables immune checkpoint blockade therapy by boosting type I interferon response.

This study shows that VHL loss in ccRCC enhances anti-PD-1 therapy efficacy by increasing type I interferon response through HIF1/HIF2-mediated mtDNA leakage.

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Senescence of endplate osteoclasts induces sensory innervation and spinal pain

This study identifies senescent osteoclasts in spinal models as contributors to pain through nerve growth and vessel formation, showing their removal reduces hypersensitivity.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

Lymphotoxin-β Promotes Bone Colonization and Osteolytic Outgrowth of Indolent Bone Metastatic cells of Breast Cancer

This study identifies lymphotoxin-β as a key factor promoting bone colonization and osteolytic outgrowth of breast cancer metastatic cells.

The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals

This study investigates the function of Hippo pathway kinases in the unicellular organism Capsaspora, revealing their role in regulating cell density and contractile behavior through cytoskeletal changes.

Self-extinguishing relay waves enable homeostaticcontrol of human neutrophil swarming

The paper identifies a self-extinguishing relay wave mechanism in human neutrophils that controls swarming and recruitment levels through an NADPH-oxidase-based feedback loop.

Viruses in deep-sea cold seep sediments harbor diverse survival mechanisms and remain genetically conserved within species

The paper examines viral genetic features and evolutionary patterns in deep-sea cold seep sediments, identifying diverse survival strategies and genetic conservation within species.

Cultivation of widespread Bathyarchaeia reveals a novel methyltransferase system utilizing lignin-derived aromatics

This study cultivates a Bathyarchaeia strain capable of degrading lignin via a novel methyltransferase system, suggesting its role in global anaerobic lignin remineralization.

Stimulation of platelet P2Y1 receptors by differentendogenous nucleotides leads to functional selectivity via biased signalling.

This study shows that different endogenous nucleotides activate P2Y1 receptors with functional selectivity, leading to distinct platelet responses in inflammation versus haemostasis.

A novel batokine Breg controls adipose thermogenesis and glucose homeostasis

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

Structural basis of a high-affinity antibody binding to glycoprotein region with consecutive glycosylation sites

This paper reports a high-affinity antibody that binds to a glycopeptide with consecutive glycosylation sites, showing that glycan modification near the epitope significantly increases antigenicity.

A Novel Selective ERK1/2 Inhibitor, Laxiflorin B, Targets EGFR Mutation Subtypes in Non-small-cell Lung Cancer

This study identifies Laxiflorin B, a novel ERK1/2 inhibitor, showing efficacy against EGFR mutant NSCLC through apoptosis induction and suppression of AREG/EREG.

Neuronal miR-138 represses HSV-2 lytic infection by regulating viral and host genes with mechanistic differences compared to HSV-1

This study shows miR-138 suppresses HSV-2 lytic infection by targeting viral and host genes, with distinct mechanisms compared to HSV-1.

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

Integrative interactome and ubiquitinome analyses reveal multiple regulatory pathways targeted by ICP0 in HSV-1 infected neuronal cells

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

This study shows that Omicron-B.1.1.529 has extensive mutations in Spike that reduce neutralization by antibodies from vaccinated and previously infected individuals, and escape most monoclonal antibodies.

Genome editing in the unicellular holozoan Capsaspora owczarzaki suggests a premetazoan role for the Hippo pathway in multicellular morphogenesis

This study uses genome editing in Capsaspora owczarzaki to show that the Hippo pathway ortholog coYki regulates cytoskeletal dynamics and multicellular shape, suggesting an ancestral role in multicellular morphogenesis.

In Situ Surface-Directed Assembly of 2D Metal Nanoplatelets for Drug-Free Treatment of Antibiotic-Resistant Bacteria

This paper develops a method to assemble copper chloride nanoplatelets on copper surfaces to enhance antibacterial properties against multi-drug-resistant E. coli.

Amino acid-derived quorum sensing molecule alanine on the GIT tolerance of the lactobacillus strains in the co-cultured fermentation model

This study investigates how L-alanine, an amino acid-derived quorum sensing molecule, enhances the gastrointestinal tolerance of Lactobacillus acidophilus in a co-culture fermentation model.

Paenibacillus sp. strain UY79, isolated from a root nodule of Arachis villosa, displays a broad spectrum of antifungal activity

This study identifies a new Paenibacillus species with broad antifungal activity and biocontrol potential, showing it can inhibit multiple plant pathogens and modulate soil bacterial communities.

Assembly principles and stoichiometry of a complete human kinetochore module

This study reconstitutes a functional full-length CENP-C protein, demonstrating its role in kinetochore assembly and showing its stoichiometry matches endogenous human kinetochores.

Deep sea sediments associated with cold seeps are a subsurface reservoir of viral diversity

The paper analyzes viral diversity in deep sea cold seep sediments, finding high endemism and links to microbial hosts and biogeochemical cycling.

An antibody drug conjugate targeting a GSTA glycosite-signature epitope of mucin1 expressed by non-small cell lung cancer

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.