Translation rescue by targeting Ppp1r15a upstream open reading frame in vivo
A. Kidwell, S. P. S. Yadav, B. Maier, A. Zollman, K. Ni, A. Halim, D. Janosevic, J. Myslinski, F. Syed, L. Zeng, A. Bopda Waffo, K. Banno, X. Xuei, E. H. Doud, P. C. Dagher, T. Hato
This study shows that targeting the Ppp1r15a upstream open reading frame rescues translation and improves kidney function in sepsis by overcoming uORF-mediated repression.
bioRxiv · Dec 11, 2021Physiology