Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
I. Greenberg, E. Sokol, A. Klein Goldberg, D. Simkin, M. Benhamou, S. Bar-Shira, M. Raz, R. Grossman, E. Yeini, P. Ofek, B. Liang, R. Satchi-Fainaro, H. Reuveni, T. Rubinek, I. Wolf
This study identifies IRS2 amplification as a driver of brain metastases in colorectal cancer, showing its role in promoting tumor growth through β-catenin and OXPHOS pathways, and suggests NT219 as a potential therapeutic target.
bioRxiv · Jun 10, 2022 · PreprintCancer Biology