B. Liang

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Targeting Iron - Respiratory Reciprocity Promotes Bacterial Death

The paper identifies a non-lytic bactericidal mechanism in P. aeruginosa by targeting multiple transporters and transcription, leading to respiratory suppression and bacterial death.

Protease-mediated degradation of the master transcription factor controls quorum sensing-state transitions in Vibrio

This study identifies PTSP as a ligand that induces proteolytic degradation of SmcR, controlling quorum sensing state transitions in Vibrio species.

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

This study maps ovarian cancer spatial organization and identifies immune evasion drivers through single-cell spatial transcriptomics and CRISPR screens.

SIX4 Controls STING Expression Enhancing anti-PD-1 Efficacy

This study identifies SIX4 as a regulator of STING expression in colon cancer, showing it enhances anti-PD-1 therapy efficacy by promoting STING activation and CD8+ T-cell infiltration.

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 Gamma variant

This study compares glycosylation and antigenicity of SARS-CoV-2 Wu-1 and Gamma variants, finding that an NTD mutation alters glycan site occupancy but not antibody binding.

An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.

The molecular mechanism of chloramphenicol and thiamphenicol resistance mediated by a novel oxidase CmO in Sphingomonadaceae

This paper identifies and characterizes a novel oxidase gene cmO in Sphingomonadaceae that mediates chloramphenicol and thiamphenicol resistance through oxidative inactivation.

Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2

This study identifies IRS2 amplification as a driver of brain metastases in colorectal cancer, showing its role in promoting tumor growth through β-catenin and OXPHOS pathways, and suggests NT219 as a potential therapeutic target.

Comparative genomic and crystal structure analyses identify a collagen glucosyltransferase from Acanthamoeba Polyphaga Mimivirus

The paper identifies a collagen glucosyltransferase in Acanthamoeba Polyphaga Mimivirus through genomic and structural analysis, revealing its unique enzymatic activity and substrate specificity.

Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine

A single dose of a SARS-CoV-2 spike vaccine delivered via a high-density microarray patch provides complete protection against a lethal virus challenge.

Categorical edge-based analyses of phylogenomic data reveal conflicting signals for difficult relationships in the avian tree

This study uses edge-based analysis to examine phylogenomic conflicts in avian evolution, revealing gene-specific biases and data type effects that impact resolution of contentious nodes.

Occurrence of COVID-19 symptoms during SARS-CoV-2 infection defines waning of humoral immunity

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

The basis of a more contagious 501Y.V1 variant of SARS-COV-2

This paper investigates the increased transmissibility of the SARS-CoV-2 501Y.V1 variant due to the N501Y mutation in the Spike protein's RBD and its impact on ACE2 binding and vaccine efficacy.

Mechanical Efficiency Investigation of an ankle-assisted robot for human walking with a backpack-load

This study evaluates the mechanical efficiency of an ankle-assisted robot during walking with varying loads, finding that efficiency decreases as device weight increases.

Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers predicting HBsAg loss

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

In-Vivo Toxicity Studies and In-Vitro Inactivation of SARS-CoV-2 by Povidone-iodine In-situ Gel Forming Formulations

This study evaluates the virucidal activity and safety of Povidone-iodine in-situ gel formulations against SARS-CoV-2 in vitro and in vivo.

Integrin αvβ8 on T cells is responsible for suppression of anti-tumor immunity in multiple syngeneic models and is a promising target for tumor immunotherapy

This study shows that blocking integrin αvβ8 on T cells enhances anti-tumor immunity in multiple syngeneic models and is effective even when tumor cells do not express the integrin.

A novel vaccine targeting the viral protease cleavage sites protects Mauritian cynomolgus macaques against vaginal SIVmac251 infection

A vaccine targeting viral protease cleavage sites provides >80% protection against vaginal SIVmac251 infection in macaques by inducing T cell responses and a protective immune environment.

Vector bionomics and vectorial capacity as emergent properties of mosquito behaviors and ecology

The paper develops a new simulation framework to model mosquito behavior and ecology, showing vectorial capacity emerges from interactions between behavioral algorithms and resource landscapes.

Segmentation of Glomeruli Within Trichrome Images Using Deep Learning

This paper develops a deep learning framework to segment glomeruli in trichrome-stained kidney biopsy images, achieving high accuracy in distinguishing glomerular regions.

Evolution of Portulacineae marked by gene tree conflict and gene family expansion associated with adaptation to harsh environments

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.