Cancer BiologybioRxivPreprint
Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
I. Greenberg, E. Sokol, A. Klein Goldberg…·I. Wolf
This study identifies IRS2 amplification as a driver of brain metastases in colorectal cancer, showing its role in promoting tumor growth through β-catenin and OXPHOS pathways, and suggests NT219 as a potential therapeutic target.
DOI 10.1101/2022.06.10.495658