Author

D. Simkin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:proteomics· 1

Frequent Co-Authors

I. Tirosh· 2 shared M. L. Suva· 2 shared A. C. Greenwald· 1 shared A. Gavish· 1 shared A. Klein Goldberg· 1 shared A. R. Greenwald· 1 shared A. Spitzer· 1 shared A. Tirosh· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

I. Tirosh

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Author profile →

3 papers

Recent·Most cited

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

A. C. Greenwald, N. G. Darnell, R. Hoefflin, D. Simkin, L. N. Gonzalez-Castro, C. Mount, D. Hirsch, M. Nomura, T. Talpir, M. Kedmi, I. Goliand, G. Medici, B. Li, H. Keren-Shaul, M. Weller, , I. Tirosh

This study uses spatial transcriptomics and proteomics to reveal three modes of cellular organization in glioblastoma, with hypoxia driving a 5-layered global architecture.

bioRxiv · Jul 6, 2023Cancer Biology

Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2

I. Greenberg, E. Sokol, A. Klein Goldberg, D. Simkin, M. Benhamou, S. Bar-Shira, M. Raz, R. Grossman, E. Yeini, P. Ofek, B. Liang, R. Satchi-Fainaro, H. Reuveni, T. Rubinek, I. Wolf

This study identifies IRS2 amplification as a driver of brain metastases in colorectal cancer, showing its role in promoting tumor growth through β-catenin and OXPHOS pathways, and suggests NT219 as a potential therapeutic target.

bioRxiv · Jun 10, 2022 · PreprintCancer Biology

The transcriptional hallmarks of intra-tumor heterogeneity across a thousand tumors

A. Gavish, M. Tyler, D. Simkin, D. Kovarsky, L. N. Gonzalez Castro, D. Halder, R. Chanoch-Myers, J. Laffy, M. Mints, A. R. Greenwald, A. Weider, R. Tal, A. Spitzer, T. Hara, A. Tirosh, , I. Tirosh

This study integrates single-cell RNA-seq data from 1,163 tumors across 24 types to identify 41 consensus transcriptional programs and 11 hallmarks of intra-tumor heterogeneity.

bioRxiv · Dec 19, 2021 · PreprintCancer Biology