Cancer BiologybioRxiv
Synergistic Combination of Cytotoxic Chemotherapy and Cyclin Dependent Kinase 4/6 Inhibitors in Biliary Tract Cancers
M. Arora, J. M. Bogenberger, A. M. Abdelrahman…·M. J. Borad
This study shows that combining gemcitabine/cisplatin with CDK4/6 inhibitors improves efficacy and reduces toxicity in biliary tract cancers through mechanisms involving autophagy and RRM1 reduction.
DOI 10.1002/hep.32102