Directed Differentiation of Human iPSCs to Functional Ovarian Granulosa-Like Cells via Transcription Factor Overexpression
Merrick Pierson Smela, Christian Clark Kramme, Patrick R.J. Fortuna…·George McDonald Church
This study generates functional ovarian granulosa-like cells from human iPSCs by overexpressing NR5A1 and RUNX1 or RUNX2, enabling the formation of ovary-like organoids with germ cells.