A naturally evolved mutation in cavefish mc3r reshapes energy homeostasis across development in a nutrient-limited environment.
Tyler Guzman, Tathagata Biswas, Vikas Tiwari, Edward Thum, Kyle Weaver, Kym M. Delventhal, Jonathan Wren, Cassidy Petree, Gaurav K. Varshney, Michael C. Rudolph, Chris W. Seidel, Nicolas Rohner, Jaya Krishnan
This study identifies a naturally evolved mutation in mc3r that alters energy homeostasis across development in cavefish, contributing to adaptation to nutrient scarcity.
bioRxiv · Oct 2, 2026 · PreprintEvolutionary Biology