Michael C. Rudolph

This study shows tamoxifen reduces subcutaneous adipocyte progenitor self-renewal and adipogenesis by suppressing Wisp2, linking endocrine therapy to metabolic risks like T2D.

This study identifies a naturally evolved mutation in mc3r that alters energy homeostasis across development in cavefish, contributing to adaptation to nutrient scarcity.

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

This study shows that large adipocytes release lipids via extracellular vesicles, promoting breast cancer cell migration and proliferation, and links this to human dyslipidemia and triglyceride levels.

This study shows Disulfiram protects against obesity and insulin resistance through GSDMD-independent mechanisms by reprogramming systemic lipid handling.

This study identifies ETV4 as a mediator of FGF1-driven proliferation and glycolysis in ER-positive breast cancer, linking obesity-related FGF1 production to tumor progression.

This study shows that the Wnt/lipogenesis axis mediates lipodystrophy and recovery in skin fibrosis by regulating lipid content and extracellular matrix.

This study shows that maternal exercise during lactation improves milk fatty acid composition and enhances offspring energy expenditure in obese dams.

The paper identifies gene expression patterns and regulatory elements associated with HMO biosynthesis in lactocytes using scRNA-seq and HMO concentration data.

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

The paper identifies genetic loci influencing milk gene expression and links these to infant gut microbiome composition in breastfeeding mothers.

The paper investigates the association between human cytomegalovirus in breast milk and milk composition, infant gut microbiome, and infant growth.

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

This study shows that deleting melanocortin-4 receptors on hypothalamic astrocytes increases body weight, feeding, and central inflammation, independent of neuronal MC4R effects.