NeuroscienceMolecular PsychiatryPeer-reviewed
Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage
Nadine Huber, Tomi Hietanen, Sami Heikkinen…·Annakaisa Haapasalo
This study shows that iPSC-derived neurons from FTD patients exhibit synaptic dysfunction, DNA damage, and C9-HRE-related pathologies, supporting synaptic dysfunction as a key factor in FTD.
4 citations