Cell BiologybioRxivPreprint
RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling
Rosalie Heilig, Hannah Glover, Charlotte E. L. Mellor…·Stephen WG Tait
This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.
DOI 10.64898/2026.09.21.752888