Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis
Abel Martín-Garrido, Nadine Weyrauch, Jorge Ruiz‐Orera, Jeanette Eresch, Sonja Reitter, Julio Cordero, Frauke Senger, Viktoria Scheich, Andrea Grund, Merve Keleş, Nina Weinzierl, Ellen Hofmann, Felix A. Trogisch, Shruthi Hemanna, Michael Buettner, , Joerg Heineke
This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.
bioRxiv · Feb 18, 2026 · PreprintPhysiology