Georg Stoecklin

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

The paper shows that CPSF5 repression leads to transcript shortening and increased pro-inflammatory gene expression in macrophages and sepsis patients.

The paper identifies NMD targets and activity in cardiomyocytes using SMG1 inhibition and RNA sequencing, showing conserved targets and reduced efficiency with UPF1/UPF2 knockdown.

ViREn is a two-step method that purifies dengue virus RNA with high purity, revealing a 5-methylcytosine modification mediated by NSUN6 that affects RNA turnover.

The paper shows that genomic G quadruplexes regulate mRNA splicing by recruiting RNA-binding proteins, with implications for cardiac function.

This study shows MEK1/2 inhibitors reduce AXIN1 levels in CRC by mTOR-dependent translational repression, not by affecting protein stability.

This study investigates the interaction between m6A and A-to-I RNA modifications in macrophages, showing that ~60% of genes are m6A-modified and ~12% have A-to-I editing sites, with ~10% overlapping.

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

This study shows arginine-rich CPPs like (PR)n displace DNA- and RNA-binding factors, impairing nucleic acid processes and causing toxicity, similar to PROTAMINE's effects.