The in vivo inhibitory function of the MHC-I alpha3 domain/CD8alpha interaction
Jing Zhao, Lawrence Feng, Yang Xu, Kareem Alsbei, Jun Wang, Tiffany Zhou, Qipeng Zhan, Shiya Sun, Eric Hong, Lingbin Meng, Ning Jin, Xiaolin Cheng, Haitao Wen, Gang Xin, Mark Rubinstein, , Linghua Zheng
This study identifies the MHC-I alpha3 domain-CD8 interaction as an inhibitory pathway that restrains CD8+ T-cell activation and maintains tolerance in vivo.
bioRxiv · May 26, 2026 · PreprintImmunology