Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification
Xiaoli Wang, Jie Ren, Fei Fang, Erxiang Wang, Jianwei Li, Weihong He, Zhen Zhang, Yang Shen, Xiaoheng Liu
This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.
bioRxiv · Apr 18, 2024Cell Biology