Author

Zhen Zhang

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Biochemistry· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Aiying Liu· 1 shared Alexander D. BershadskyiD· 1 shared Arthur D. LaganowskyiD· 1 shared Buqing Ni· 1 shared Erxiang Wang· 1 shared Fei FangiD· 1 shared Gareth E. Jones· 1 shared Haibin Ji· 1 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

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1 shared paperGenomics

Aiying Liu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mechanism of substrate recognition and catalysis in a mammalian phosphatidylserine synthase 2

Lie Wang, Zhen Zhang, Hongyuan Yang, Arthur D. Laganowsky, Ming Zhou

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

Proceedings of the National Academy of Sciences · Sep 29, 2026Peer-reviewedBiochemistry

Anti-IL1RAP Antibodies for Pan-Inhibition of IL-1 Family Cytokine Signaling in Inflammatory Diseases and Oncology

Qinghao Liu, Yanxia Wang, Yan Jiang, Yaqi Ru, Qian Zhao, Zhen Zhang, Zhiqiang Li, Qian Shi, Yunlong Cao

Anti-IL1RAP antibodies block multiple IL-1 family cytokines simultaneously, showing superior efficacy in inflammation and cancer models.

bioRxiv · Feb 16, 2026 · PreprintImmunology

NPAS2 attenuates VSMC phenotypic switching in ascending thoracic aortic aneurysm via LPCAT3/PC-PUFA2S-mediated ferroptosis

Wenfeng Lin, Jiaqi Xiong, Yuhan Yan, Jinhui Bian, Zhen Zhang, Xinyang Xu, Yifei Diao, Xiaoxia Lan, Yu Zhong, Haibin Ji, Yongfeng Shao, Buqing Ni

This study identifies NPAS2 as a regulator of VSMC phenotypic switching in ATAA by modulating LPCAT3/PC-PUFA2S-mediated ferroptosis.

bioRxiv · Sep 23, 2025 · PreprintMolecular Biology

A Novel 'Three-in-one' Mucosal Vaccine Elicits Broad Protection against Three Distinct Clusters of ACE2-using Sarbecoviruseses

Lin Liu, Haofeng Lin, Min Li, Xian Li, Shasha Wang, Mengxin Xu, Shuning Liu, Yunqi Hu, Meiqin Liu, Zhixiang Huang, Zhen Zhang, Ke Lan, Yu Zheng Chen, Huimin Yan, Li Zhou, , Qingguo Wu

This paper develops a three-in-one mucosal vaccine, 3Rs-NC, that elicits broad neutralizing antibodies against three ACE2-using sarbecovirus clusters and provides durable protection in mice.

bioRxiv · Jun 26, 2025 · PreprintImmunology

Matrix Vesicles from Osteoblasts Promote Atherosclerotic Calcification

Xiaoli Wang, Jie Ren, Fei Fang, Erxiang Wang, Jianwei Li, Weihong He, Zhen Zhang, Yang Shen, Xiaoheng Liu

This study shows osteoblast-derived matrix vesicles (Ost-MVs) contribute to atherosclerotic calcification by being released into circulation and transported to plaques, where they exacerbate calcification through the Ras-Raf-ERK pathway.

bioRxiv · Apr 18, 2024Cell Biology

The cytoskeleton as a smart composite material: A unified pathway linking microtubules, myosin-II filaments and integrin adhesions

Nisha Bte Mohd Rafiq, Yukako Nishimura, Sergey V. Plotnikov, Visalatchi Thiagarajan, Zhen Zhang, Meenubharathi Natarajan, Shidong Shi, Virgile Viasnoff, Gareth E. Jones, Pakorn Kanchanawong, Alexander D. Bershadsky

This paper identifies KANK proteins as mediators linking microtubules to integrin adhesions, showing how microtubule disconnection triggers myosin-IIA filament assembly and remodeling of focal adhesions and podosomes.

bioRxiv · Jul 17, 2018 · PreprintCell Biology

Transcriptome analysis revealed the possible contribution of chromosome introgression fragments from Sea Island cotton (Gossypium barbadense) to fiber strength in Upland cotton (Gossypium hirsutum)

Quanwei Lu, Yuzhen Shi, Xianghui Xiao, Pengtao Li, Juwu Gong, Aiying Liu, Haihong Shang, Wankui Gong, Tingting Chen, Qun Ge, Junwen Li, Wei Su, Shaoqi Li, Zhen Zhang, Youlu Yuan, Jinling Huang

The study identifies differentially expressed genes and functional genes associated with fiber strength in Upland cotton introgression lines with Sea Island cotton fragments.

bioRxiv · Sep 6, 2016 · PreprintGenomics