Cell BiologybioRxiv
TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery
Bhaskar Saha, Hallvard Olsvik, Geneva L. Williams…·Michael A. Mandell
The paper shows TRIM5 ubiquitinates TBK1 to assemble mitophagy machinery on damaged mitochondria, essential for both Parkin-dependent and independent mitophagy.
DOI 10.1016/j.celrep.2024.114294