Author

Evan Zhang

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 2 Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrew C. LuiD· 2 shared Kevin Ho· 2 shared Lukas MoelleriD· 2 shared Michael B. ElowitziD· 2 shared Albert Qiang· 1 shared Ali Ahmed Diaz· 1 shared Ayush VarshneyiD· 1 shared Bo GuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSynthetic Biology

Andrew C. LuORCID

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3 papers

Recent·Most cited

Engineered caspases directly rewire mutant Ras to cell death

Lukas Moeller, Andrew C. Lu, Kevin Ho, Evan Zhang, Michael B. Elowitz

This paper engineers caspases to selectively kill cells with mutant Ras by reconstituting active complexes upon detection, showing potent in vitro efficacy against cancer lines.

bioRxiv · Sep 3, 2026 · PreprintSynthetic Biology

Flow Autoencoders are Effective Protein Tokenizers

Rohit Dilip, Evan Zhang, Ayush Varshney, David Van Valen

The paper introduces Kanzi, a flow-based tokenizer for protein structures that simplifies training and outperforms existing tokenizers on reconstruction metrics.

bioRxiv · Oct 1, 2025 · PreprintBioengineering

Engineered protein circuits for cancer therapy

Andrew C. Lu, Lukas Moeller, Stephen Moore, Kevin Ho, Victoria Tobin, Albert Qiang, Evan Zhang, Zhijie Li, Mengmeng Wang, Shiyu Xia, Mark W. Budde, Haley Larson, Ali Ahmed Diaz, Bo Gu, James M. Linton, , Michael B. Elowitz

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

bioRxiv · Apr 16, 2025 · PreprintSynthetic Biology