Author

Lukas Moeller

California Institute of TechnologyORCID 0000-0002-4375-8837Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Synthetic Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:protein structure· 1

Frequent Co-Authors

Andrew C. LuiD· 2 shared Evan Zhang· 2 shared Kevin Ho· 2 shared Michael B. ElowitziD· 2 shared Albert Qiang· 1 shared Ali Ahmed Diaz· 1 shared Bo GuiD· 1 shared Daniel J. SiegwartiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Andrew C. LuORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintSep 3, 2026

Engineered caspases directly rewire mutant Ras to cell death

Lukas Moeller, Andrew C. Lu, Kevin Ho…·Michael B. Elowitz

This paper engineers caspases to selectively kill cells with mutant Ras by reconstituting active complexes upon detection, showing potent in vitro efficacy against cancer lines.

DOI 10.64898/2026.08.06.743376

humanexperimental assay

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintApr 16, 2025

Engineered protein circuits for cancer therapy

Andrew C. Lu, Lukas Moeller, Stephen Moore…·Michael B. Elowitz

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

DOI 10.1101/2025.04.16.647665

humanprotein structure

𝕏 PostBluesky