Stephen Moore

A Course-Undergraduate Research Experience (CURE) to explore the effect of structural variants on gene expression in C. elegans balancers

Students investigated structural variants' effects on gene expression in C. elegans balancers using bioinformatics tools and reported molecular mechanisms and unexpected gene expression effects.

Ultrafast X-Rays Capture Retinal Traversing Conical Intersection in Rhodopsin

This study uses ultrafast X-ray scattering to observe retinal cis-trans isomerization in rhodopsin, revealing how cofactor dynamics drive activation without crystal lattice constraints.

Interrogation of the glycolytic axis in pulmonary arterial hypertension models and how modifying these can lead to potential therapeutic options.

This paper investigates the glycolytic axis in PAH models and shows that TEPP-46 treatment reduces nuclear PKM2 and improves PAH symptoms in rodent models.

Engineered protein circuits for cancer therapy

This paper engineers protease-based protein circuits that selectively kill RAS-mutant cancer cells and suppress tumors, showing resistance reduction and cytotoxicity independent of oncogene addiction.

Interleukin-6 is critical in the development of gcn2-mutation associated pulmonary vascular disease in mice

This study shows that interleukin-6 is critical in gcn2-mutation associated pulmonary vascular disease in mice, as its deletion rescues pulmonary hypertension phenotypes.

VISTA-induced tumor suppression by a four amino acid intracellular motif

This study identifies a four amino acid motif in VISTA that suppresses tumor growth by altering EGFR signaling through NUMB recruitment.

A deep intronic variant activates a pseudoexon in the MTM1 gene in a family with X-linked myotubular myopathy

The paper identifies an intronic variant in MTM1 that activates a pseudoexon, leading to nonsense-mediated decay and causing X-linked myotubular myopathy in affected males.