GeneticsbioRxivPreprint
Reduced Gene Dosage of Histone H4 Prevents CENP-A Mislocalization in Saccharomyces cerevisiae
Jessica R. Eisenstatt, Kentaro Ohkuni, Wei-Chun Au…·Munira A. Basrai
This study identifies genes that contribute to mislocalization of overexpressed Cse4 and shows reduced H4 dosage facilitates Cse4 sumoylation and mislocalization, leading to synthetic dosage lethality.
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