BioinformaticsbioRxivPreprint
IDH1 and IDH2 mutants identified in cancer lose inhibition by isocitrate because of a change in their binding sites
Juan Pablo Bascur, Melissa Alegría‐Arcos, Ingrid Araya‐Durán…·Daniel Eduardo Almonacid
This paper identifies how IDH1 and IDH2 mutations lose inhibition by isocitrate due to changes in their binding sites, using molecular docking and binding site analysis.
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