Structure-based similarity network accelerates the discovery of lysins as oral microbiome modulators targeting periodontal pathogens
Fangfang Yao, Jiajun He, Raphael Nyaruaba, F Chen, Jiannan Zhou, Hang Yang, Hongping Wei, Yuhong Li
The paper identifies potent periodontal lysins using a structure-based pipeline and shows LysPd078 effectively modulates oral microbiome communities in preclinical models.
bioRxiv · Apr 13, 2026 · PreprintMicrobiology