Author

Fangfang Yao

Wuhan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:protein structure· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Hongping WeiiD· 3 shared Jiajun HeiD· 3 shared Yuhong LiiD· 2 shared F Chen· 1 shared Fangyuan Chen· 1 shared Fen Hu· 1 shared Hang Yang· 1 shared Hang YangiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Hongping WeiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering Dual-Target Chimeric Lysins for Synergistic Eradication of Porphyromonas gingivalis

Fangfang Yao, Jiajun He, Fangyuan Chen, Tianshu Chu, Hongping Wei, Yuhong Li

This study engineers dual-target chimeric lysins to eradicate Porphyromonas gingivalis in periodontitis, showing significant bactericidal activity and reduced inflammation in a mouse model.

bioRxiv · Apr 29, 2026 · PreprintMicrobiology

Structure-based similarity network accelerates the discovery of lysins as oral microbiome modulators targeting periodontal pathogens

Fangfang Yao, Jiajun He, Raphael Nyaruaba, F Chen, Jiannan Zhou, Hang Yang, Hongping Wei, Yuhong Li

The paper identifies potent periodontal lysins using a structure-based pipeline and shows LysPd078 effectively modulates oral microbiome communities in preclinical models.

bioRxiv · Apr 13, 2026 · PreprintMicrobiology

Dimer-monomer transition defines a hyper-thermostable peptidoglycan hydrolase mined from bacterial proteome by lysin-derived antimicrobial peptide-primed screening

Li Zhang, Fen Hu, Zirong Zhao, Xinfeng Li, Mingyue Zhong, Jiajun He, Fangfang Yao, Xiaomei Zhang, Yuxuan Mao, Hongping Wei, Jin He, Hang Yang

The paper identifies hyper-thermostable peptidoglycan hydrolases from bacterial proteomes using lysin-derived antimicrobial peptide screening and shows their potent bactericidal activity.

eLife · Nov 26, 2024Peer-reviewedBiochemistry