The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma
M. Wu, A. Hanly, F. Gibson, K. H. Kuang, J. Kalin, S. Nocco, M. Collard, M. W. Cole, A. Xiao, F. Agus, A. Labadorf, P. A. Cole, R. M. Alani
This study identifies the CoREST repressor complex as a mediator of melanoma phenotype switching and therapy resistance, showing that its inhibitor corin can reverse resistance to BRAF inhibitors.
bioRxiv · Sep 30, 2020Cancer Biology