Cancer BiologybioRxiv
The CoREST Repressor Complex Mediates Phenotype Switching and Therapy Resistance in Melanoma
M. Wu, A. Hanly, F. Gibson…·R. M. Alani
This study identifies the CoREST repressor complex as a mediator of melanoma phenotype switching and therapy resistance, showing that its inhibitor corin can reverse resistance to BRAF inhibitors.
DOI 10.1172/jci171063