M. Wu

Cnidaria XIAP activates caspase-mediated cell death

This study investigates the function of XIAP in Cnidaria, showing it activates caspase-mediated cell death through BIR and RING domains, unlike its vertebrate counterpart.

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation.

This study shows the WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation through in vivo biochemical approaches.

Spatial proteomic mapping of human nuclear bodies reveals new functional insights into RNA regulation

The paper maps human nuclear bodies using proximity proteomics, identifying new components and regulatory functions in RNA regulation.

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

This study identifies an enhancer of Ctnnb1 that regulates Wnt signaling dosage, maintaining intestinal homeostasis and suppressing colorectal cancer.

Metabolic analysis in intact human-derived cerebral organoids by high-resolution magic-angle spinning NMR spectroscopy

This study uses HR-MAS NMR to analyze metabolism in human-derived cerebral organoids at different developmental stages, finding a metabolic profile similar to the human brain with some differences.

A vacuolar invertase gene SlVI modulates sugar metabolism and postharvest fruit quality and resistance in tomato

This study investigates the role of the tomato vacuolar invertase gene SlVI in sugar metabolism, fruit quality, and postharvest resistance, finding that its knockout increases sucrose content, firmness, and resistance to Botrytis cinerea.

Vimentin promotes collective cell migration through collagen networks via increased matrix remodeling and spheroid fluidity

A unifying model of species abundance distribution

The paper shows that the powerbend distribution unifies species abundance patterns across all life forms, rejecting pure neutrality and supporting a mix of random and deterministic ecological processes.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

HIF1α controls adipose tissue growth through metabolic rechanneling

This study shows that HIF1α is essential for adipose tissue growth under normal conditions and in response to high-fat diets, by rechanneling metabolic intermediates into lipid synthesis.

Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases

The paper identifies a new family of RiPPs in lactic acid bacteria biosynthetic gene clusters, revealing a novel adenylyltransferase mechanism for macrocyclic imide formation.

Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

The impact of Bacillus coagulans X3 on available nitrogen content, bacterial community composition, and nitrogen functional gene levels when composting cattle manure

This study examines how adding Bacillus coagulans X3 to cattle manure compost affects nitrogen levels, bacterial communities, and nitrogen-related genes.

High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.

This study evaluates the Gatan Alpine detector at 100-200 keV for cryo-EM, showing improved resolution and performance compared to the Gatan K3.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Reductive dehalogenation by diverse microbes is central to biogeochemical cycles in deep-sea cold seeps

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

Engineering Planar Gram-Negative Outer Membrane Mimics Using Bacterial Outer Membrane Vesicles

This study develops a method to create planar bacterial outer membrane mimics using OMVs, enabling antibiotic development studies by replicating the gram-negative membrane barrier.

VaxSeer: Selecting influenza vaccines through evolutionary and antigenicity models

VaxSeer selects influenza vaccine strains using evolutionary and antigenicity models to predict future effectiveness, outperforming annual recommendations.

Metabolic interactions of a minimal bacterial consortium drive robust nitritation at acidic pH

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

Identification of CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices

This study identifies CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices, showing its role in modulating collagen network mechanics and tumor invasion.

Local structural flexibility drives oligomorphism in computationally designed protein assemblies

This study shows that structural flexibility in computationally designed protein assemblies leads to multiple architectures, expanding their functional possibilities.

Injury induced renal fibrosis promotes cystogenesis and cyst growth in adult mice with autosomal dominant polycystic kidney disease

This study shows that renal fibrosis induced by injury promotes cyst formation and growth in adult ADPKD mice, and targeting EZH2 can reduce fibrosis and cyst growth.

Chromatinization Modulates Topoisomerase II Processivity

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

Microinterfaces in bicontinuous hydrogels guide rapid 3D cell migration

This study develops a bicontinuous hydrogel system that enables rapid 3D cell migration by leveraging microinterfaces, showing mesenchymal behavior across multiple contexts.

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle

This study shows that the IRE1α/XBP1 signaling pathway promotes myoblast fusion in skeletal muscle by upregulating profusion genes like Myomaker, crucial for muscle regeneration.

Competition and Synergy of Arp2/3 and Formins in Nucleating Actin Waves

This study investigates the interplay between formins and Arp2/3 complex in cortical actin wave dynamics, revealing both cooperation and antagonism regulated by Cdc42.

Simultaneous multimodal three-photon and optical coherence microscopy of the mouse brain in the 1700 nm optical window in vivo

This paper demonstrates a multimodal imaging system combining three-photon microscopy and optical coherence microscopy in vivo for deep brain imaging with high resolution.

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.