Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AML
L. Nicosia, F. L. Boffo, E. Ceccacci, I. Pallavicini, F. Bedin, E. Massignani, R. Ravasio, S. Minucci, T. Bonaldi
This study shows that LSD1 inhibitors induce AML cell differentiation by reducing GSE1, a novel oncogene, through transcriptional activation of immune response genes.
bioRxiv · Feb 16, 2021 · PreprintCancer Biology