EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake
D. Pirri, S. Tian, B. Tardajos Ayllon, S. Irving, F. Donati, S. Allen, T. Mammoto, G. Vilahur, C. L. Miller, T. Schenkel, E. Chambers, M. J. Dunning, J. Serbanovic-Canic, F. Botre, A. Mammoto, , P. C. Evans
This study shows EPAS1 reduces atherosclerosis at disturbed flow sites by promoting endothelial fatty acid uptake and metabolism, which is suppressed in obesity through triglyceride-PHD3 pathway.
bioRxiv · Dec 5, 2023Physiology