C. L. Miller

Variability of morphology-performance relationships under acute exposure to different temperatures in three strains of zebrafish.

This study examines how morphology-performance relationships vary with temperature in three zebrafish strains, finding temperature-independent and -dependent patterns of swimming speed variation.

EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake

This study shows EPAS1 reduces atherosclerosis at disturbed flow sites by promoting endothelial fatty acid uptake and metabolism, which is suppressed in obesity through triglyceride-PHD3 pathway.

CREATION AND CHARACTERIZATION OF A RECOMBINANT MAMMALIAN ORTHOREOVIRUS EXPRESSING HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 PEPTIDES

This paper creates and characterizes a recombinant mammalian orthoreovirus expressing HER2 peptides to enhance oncolytic activity against HER2+ breast cancer cells.

Sequences at gene segment termini inclusive of untranslated regions and partial open reading frames play a critical role in mammalianorthoreovirus S gene packaging

This study identifies packaging signals in mammalian orthoreovirus S gene segments, showing that terminal sequences including UTRs and ORF parts are critical for viral packaging.

Mammalian orthoreovirus infection in human epidermal growth factor receptor 2 positive (HER2+) breast cancer cells

This study shows that mammalian orthoreovirus (MRV) infects and kills HER2+ breast cancer cells, reduces HIF-1 accumulation, and may enhance trastuzumab efficacy.

The contribution of mutation to variation in temperature-dependent sprint speed in zebrafish, Danio rerio

This study examines how mutations affect temperature-dependent sprint speed in zebrafish, finding that mutational effects are consistently correlated across temperatures, suggesting synergistic cross-environment effects.

Design of a mucin-selective protease for targeted degradation of cancer-associated mucins

This paper designs a mucin-selective protease conjugated to a nanobody to degrade cancer-associated mucins, showing reduced tumor growth in mouse models.

Inhibition of HIF-1α accumulation in prostate cancer cells is initiated during early stages of mammalian orthoreovirus infection

This study identifies the stage of mammalian orthoreovirus infection required to inhibit HIF-1α accumulation in prostate cancer cells, linking it to virus core movement across the endosomal membrane.

Characterization of a replicating mammalian orthoreovirus with tetracysteine tagged μNS for live cell visualization of viral factories

This paper develops a method to visualize viral factories (VFs) in live cells by tagging the NS protein of mammalian orthoreovirus with a tetracysteine (TC) tag and using FlAsH-EDT2 reagent, revealing dynamic VF movement and microtubule dependence.

Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1

This paper shows that MRV non-structural protein σNS interacts with G3BP1 to relocalize stress granule proteins to virus factories, disrupting SG formation and enhancing viral replication.