Author

E. Chambers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pathology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Tardajos Ayllon· 2 shared D. Pirri· 2 shared J. Serbanovic-Canic· 2 shared M. Fragiadaki· 2 shared A. J. Aguirre· 1 shared A. Jones· 1 shared A. Mammoto· 1 shared A. Regev· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

B. Tardajos Ayllon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake

D. Pirri, S. Tian, B. Tardajos Ayllon, S. Irving, F. Donati, S. Allen, T. Mammoto, G. Vilahur, C. L. Miller, T. Schenkel, E. Chambers, M. J. Dunning, J. Serbanovic-Canic, F. Botre, A. Mammoto, , P. C. Evans

This study shows EPAS1 reduces atherosclerosis at disturbed flow sites by promoting endothelial fatty acid uptake and metabolism, which is suppressed in obesity through triglyceride-PHD3 pathway.

bioRxiv · Dec 5, 2023Physiology

TopoRoot: A method for computing hierarchy and fine-grained traits of maize roots from X-ray CT images

D. Zeng, M. Li, N. Jiang, Y. Ju, H. Schreiber, E. Chambers, D. Letscher, T. Ju, C. N. Topp

TopoRoot computes fine-grained root traits from maize root CT images, improving accuracy over existing methods and enabling automated analysis of root system architecture.

bioRxiv · Aug 24, 2021Plant Biology

JAG1-NOTCH4 MECHANOSENSING DRIVES ATHEROSCLEROSIS

C. Souilhol, X. Li, L. Canham, H. Roddie, D. Pirri, B. Tardajos Ayllon, E. Chambers, M. Dunning, M. Ariaans, J. Li, Y. Fang, M. FRAGIADAKI, V. Ridger, J. Serbanovic-Canic, S. De Val, , P. Evans

This study shows JAG1-NOTCH4 signaling promotes atherosclerosis by repressing endothelial repair in response to low oscillatory shear stress.

bioRxiv · May 15, 2020Pathology

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

J. M. McFarland, B. R. Paolella, A. Warren, K. Geiger-Schuller, T. Shibue, M. Rothberg, O. Kuksenko, A. Jones, E. Chambers, D. Dionne, S. Bender, B. M. Wolpin, M. Ghandi, I. Tirosh, O. Rozenblatt-Rosen, , A. Tsherniak

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

bioRxiv · Dec 8, 2019Cancer Biology