Knockout of TSPO delays and reduces amyloid, Tau, astrocytosis and behavioral dysfunctions in Alzheimer's disease.
K. Ceyzeriat, L. Meyer, F. Bouteldja, S. Tsartsalis, Q. Amosse, R. J. Middleton, G.-J. Liu, R. B. Banati, T. Zilli, V. Garibotto, P. Millet, B. B. Tournier
This study shows that knocking out TSPO in Alzheimer's disease models delays disease onset and reduces amyloid, Tau, astrocytosis, and behavioral issues.
bioRxiv · Mar 26, 2022Pathology