Author

F. D. Toste

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:protein structure· 1

Frequent Co-Authors

A. H. Christian· 1 shared B. Hann· 1 shared C. C. Ward· 1 shared C. J. Chang· 1 shared C. M. Zammit· 1 shared D. Dovala· 1 shared D. Fuller· 1 shared D. K. Nomura· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

A. H. Christian

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2 papers

Recent·Most cited

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

S. K. Elledge, H. L. Tran, A. H. Christian, V. Steri, B. Hann, F. D. Toste, C. J. Chang, J. A. Wells

This study systematically identifies engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation, finding stable sulfimide modifications comparable to cysteine-maleimide conjugation.

bioRxiv · Aug 28, 2019Bioengineering