Author

M. Knapp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Ecology· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:structural biology· 3 Research Focus:database / resource· 2 Research Focus:ecology & biodiversity· 2 Assay:metagenomics· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

D. Dovala· 3 shared A. Frommlet· 2 shared A. M. Shaqra· 2 shared A. O. Frank· 2 shared C. A. Schiffer· 2 shared D. E. Bussiere· 2 shared E. Ornelas· 2 shared L. Tandeske· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

D. Dovala

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Author profile →

9 papers

Recent·Most cited

The radiation of Austral teals and the evolution of flightlessness

H. S. Rosinger, O. Kardialsky, M. Kennedy, H. G. Spencer, F. M. Steiner, B. C. Schlick-Steiner, N. Rawlence, M. Knapp

This study presents the first whole mitogenome-based phylogeny of Austral teals, revealing their divergence from mallards in the late Miocene and radiation into flightless and volant lineages.

bioRxiv · Oct 19, 2023 · PreprintEvolutionary Biology

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses

S. N. Zvornicanin, A. M. Shaqra, Q. Y. Huang, E. Ornelas, M. Moghe, M. Knapp, S. Moquin, D. Dovala, C. A. Schiffer, N. Kurt Yilmaz

The paper determines inhibitor-bound crystal structures of main proteases from delta and gamma coronaviruses to inform structure-based inhibitor design.

bioRxiv · Feb 1, 2023 · PreprintBiochemistry

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

Defining the Substrate Envelope of SARS-CoV-2 Main Protease to Predict and Avoid Drug Resistance

A. M. Shaqra, S. Zvornicanin, Q. Y. Huang, G. J. Lockbaum, M. Knapp, L. Tandeske, D. T. Barkan, J. Flynn, D. N. Bolon, S. Moquin, D. Dovala, N. Kurt Yilmaz, C. A. Schiffer

This study defines the substrate envelope of SARS-CoV-2 main protease using cocrystal structures to identify vulnerable sites that may lead to drug resistance.

bioRxiv · Jan 25, 2022Biochemistry

Environmental DNA analysis needs local reference data to inform taxonomy-based conservation policy:A case study from Aotearoa / New Zealand

P. Czechowski, M. de Lange, M. Heldsinger, W. Rayment, C. Hepburn, M. Ladds, M. Knapp

The paper evaluates the limitations of eDNA metabarcoding for biodiversity monitoring in New Zealand fiords, showing poor taxonomic accuracy without local reference data.

bioRxiv · Oct 22, 2021 · PreprintEcology

Antarctic biodiversity predictions through substrate qualities and environmental DNA

P. Czechowski, M. de Lange, M. Knapp, A. Terauds, M. Stevens

The paper predicts Antarctic biodiversity using substrate properties and environmental DNA data to inform conservation strategies.

bioRxiv · Aug 18, 2021Ecology

DatumKB: A Database of Biological Experimental Results

M. Knapp, T. McCarthy, C. Talcott

DatumKB curates human protein function and regulation data from literature, stored as structured datums for computational analysis and pathway modeling.

bioRxiv · Jun 25, 2021 · PreprintCell Biology

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

D. E. Bussiere, L. Xie, W. Shu, H. Srinivas, W. Shu, A. Burke, C. Be, J. Zhao, A. Godbole, D. King, R. G. Karki, V. Hornak, F. Xu, J. Cobb, N. Carte, , J. Paulk

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

bioRxiv · Aug 16, 2019Biophysics

A VP2/3-derived peptide exhibits potent antiviral activity against BK and JC polyomaviruses by targeting a novel VP1 binding site

J. R. Kane, S. Fong, J. Shaul, A. Frommlet, A. O. Frank, M. Knapp, D. E. Bussiere, P. Kim, E. Ornelas, C. Cuellar, J. R. Abend, C. A. Wartchow

The paper identifies a VP2/3-derived peptide that inhibits BK and JC polyomaviruses by binding to a novel VP1 pore site, showing potent antiviral activity with low nanomolar affinity.

bioRxiv · Aug 8, 2019 · PreprintMicrobiology