Author

N. J. Henning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. K. Nomura· 3 shared J. M. McKenna· 3 shared J. N. Spradlin· 3 shared M. Schirle· 3 shared C. C. Ward· 2 shared D. Dovala· 2 shared J. A. Tallarico· 2 shared L. Boike· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBiochemistry

D. K. Nomura

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivMar 5, 2022

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala…·D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

DOI 10.1002/cbic.202300116

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistrybioRxivApr 30, 2021

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin…·D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

DOI 10.1038/s41589-022-00971-2

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivApr 15, 2021

Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications

N. J. Henning, A. G. Manford, J. N. Spradlin…·D. K. Nomura

The paper discovers a covalent ligand, EN106, that targets FEM1B for PROTAC-based protein degradation, demonstrating its utility in degrading BRD4.

DOI 10.1021/jacs.1c03980

humanproteomics

𝕏 PostBluesky