Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors
P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura
This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.
bioRxiv · Mar 5, 2022Biochemistry