F. Delolme

Scaffolding protein GspB/OutB facilitates assembly of the Dickeya dadantii type 2 secretion system by anchoring the outer membrane secretin pore to the inner membrane and to the peptidoglycan cell wall.

This paper shows that GspB scaffolds the T2SS secretin pore in Dickeya dadantii by anchoring it to the inner membrane and peptidoglycan, and identifies its conserved periplasmic domain and interactions with GspD.

A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

The paper identifies a 9-kDa SPARC fragment released by cathepsin D in TNBC that promotes tumor progression by enhancing cell migration and invasion.