Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling
M.-L. Jobin, V. De Smedt-Peyrusse, F. Ducrocq, A. Oummadi, R. Baccouch, M. Hauge Pedersen, B. Medel Lacruz, P. Van-Delft, L. Fouillen, S. Mongrand, J. Selent, T. Tolentino-Cortez, G. Barreda-Gomez, S. Gregoire, E. Masson, , P. Trifilieff
This study shows that n-3 PUFAs enhance D2R ligand binding and signaling, suggesting they act as allosteric modulators of the receptor.
bioRxiv · Jan 4, 2022Cell Biology