Author

I. Alves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein sequence· 1

Frequent Co-Authors

P. Trifilieff· 2 shared R. Baccouch· 2 shared T. Durroux· 2 shared V. De Smedt-Peyrusse· 2 shared A. A. Mali· 1 shared A. Gorse· 1 shared A. JOLIOT· 1 shared A. Oummadi· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

P. Trifilieff

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor internalization

S. Sposini, R. Baccouch, M. Lescuyer, A. A. Mali, V. De Smedt-Peyrusse, J. Heuninck, A. Gorse, T. Durroux, P. Trifilieff, D. Perrais, I. Alves

This study shows that membrane poly-unsaturated fatty acids (PUFAs) impair dopamine D2 receptor (D2R) endocytosis without affecting other GPCRs or clathrin-mediated endocytosis.

bioRxiv · Dec 14, 2023 · PreprintCell Biology

Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling

M.-L. Jobin, V. De Smedt-Peyrusse, F. Ducrocq, A. Oummadi, R. Baccouch, M. Hauge Pedersen, B. Medel Lacruz, P. Van-Delft, L. Fouillen, S. Mongrand, J. Selent, T. Tolentino-Cortez, G. Barreda-Gomez, S. Gregoire, E. Masson, , P. Trifilieff

This study shows that n-3 PUFAs enhance D2R ligand binding and signaling, suggesting they act as allosteric modulators of the receptor.

bioRxiv · Jan 4, 2022Cell Biology

Bidirectional transfer of Engrailed homeoprotein across the plasma membrane requires PIP2

I. Amblard, E. Dupont, i. Alves, J. Miralves, I. Queguiner, A. JOLIOT

The paper demonstrates that PIP2 and cholesterol are essential for Engrailed2 homeoprotein translocation across the plasma membrane, with both secretion and internalization regulated by PIP2 levels.

bioRxiv · Jan 21, 2020Cell Biology