Cell BiologybioRxiv
Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling
M.-L. Jobin, V. De Smedt-Peyrusse, F. Ducrocq…·P. Trifilieff
This study shows that n-3 PUFAs enhance D2R ligand binding and signaling, suggesting they act as allosteric modulators of the receptor.
DOI 10.1038/s41380-022-01928-6