EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor.
L. Sprinzen, F. G. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. M. Caprioli, A. Quinones-Hinojosa, P. Casaccia, P. Canoll
This study shows that EZH2 inhibition synergizes with HDAC inhibitors to kill IDH1R132H mutant glioma cells by reducing H3K27me3 and increasing H3K27ac.
bioRxiv · Jul 31, 2023Cancer Biology