L. Lei

Phenotypically wild barley shows evidence of introgression from cultivated barley

The paper examines introgression from cultivated barley into wild barley accessions, finding 16% of accessions show genetic evidence of introgression, with implications for conservation.

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

Epigenetic Control of Adaptive or Homeostatic Splicing of Alternative Exons and Prolactin Gene Expression During Interval-Training Activities of Pituitary Cells

This study shows that interval-training depolarization of pituitary cells triggers adaptive or homeostatic splicing of alternative exons, regulated by DNA methylation and MeCP2, while maintaining steady Prolactin gene expression.

Primary oocytes with cellular senescence features are involved in ovarian aging in mice

This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.

EZH2 inhibition sensitizes IDH1R132H mutant gliomas to histone deacetylase inhibitor.

This study shows that EZH2 inhibition synergizes with HDAC inhibitors to kill IDH1R132H mutant glioma cells by reducing H3K27me3 and increasing H3K27ac.

CALCIUM-DEPENDENT PROTEIN KINASE32 regulates cellulose biosynthesis through post-translational modification of cellulose synthase

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

TMT-based proteomic analysis of the antibiotic effects of ShangKeHuangShui against Straphylococcus aureus.

This study uses TMT-based proteomics to analyze the antibacterial effects of YACTH against Staphylococcus aureus, identifying 490 differentially expressed proteins and their biological pathways.

Single-cell sequencing characterizes intratumoral profile of immune cells in old mice

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

Transcriptome Profiling of different types of human respiratory tract cells infected by SARS-CoV-2 Highlight an unique Role for Inflammatory and Interferon Response

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

Identification of a plant kinase that phosphorylates the bacterial effector AvrPtoB

The paper identifies SnRK2.8 as a plant kinase that phosphorylates the bacterial effector AvrPtoB, enhancing its virulence functions.

The mouse Balbiani body maintains primordial follicle quiescence via RNA storage

This study shows the mouse Balbiani body maintains primordial follicle quiescence by storing mRNAs that are translationally inactive and regulated by 5-capping.

Computational and robotic modeling reveal parsimonious combinations of interactions between individuals in schooling fish

The paper uses computational and robotic models to show that fish schools maintain cohesion with minimal neighbor interaction, specifically by responding to the most influential neighbor.

The loss of ATRX/DAXX complex disturbs rDNA heterochromatinization and promotes development of glioma

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

Circular RNA hsa_circ_0068033 inhibits proliferation and invasion of breast cancer cells through sponging miR-659

CELLULOSE SYNTHASE INTERACTIVE1- and Microtubule-Dependent Cell Wall Architecture Is Required for Acid Growth in Arabidopsis Hypocotyls

The paper investigates the role of CSI1 and microtubules in cell wall architecture during acid growth in Arabidopsis hypocotyls, finding that CSI1-dependent crossed-polylamellate walls are essential for auxin-induced cell elongation.

Altered Bacteria-Fungi Inter-Kingdom Network in Gut of Ankylosing Spondylitis Patients

This study identifies altered fungal and bacterial interactions in the gut microbiota of Ankylosing Spondylitis patients using 16S rDNA and ITS2 sequencing.

Plant organ evolution revealed by phylotranscriptomics in Arabidopsis

The paper uses phylotranscriptomics to analyze transcriptome evolution in Arabidopsis organs, finding that seedling sense transcriptomes are the oldest and most conserved, while floral bud sense transcriptomes are the youngest and least conserved.

Temporal fitness fluctuations in experimental Arabidopsis thaliana populations

This study examines how environmental and genetic factors influence lifetime fitness in Arabidopsis thaliana across different planting seasons and locations.