Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2)
J. Goretzko, N. Heitzig, K. Thomas, E. K. Krogsaeter, J. Nass, A. L. Linard Matos, T. Wegner, S. Schloer, V. Gerke, J. Rossaint, F. Glorius, F. Bracher, C. M. Grimm, U. Rescher
The paper shows that TPC2 regulates endothelial cell surface P-selectin by controlling CD63 transfer from endosomes to Weibel-Palade bodies, affecting leukocyte recruitment during inflammation.
bioRxiv · Sep 28, 2021 · PreprintImmunology