F. Bracher

Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2)

The paper shows that TPC2 regulates endothelial cell surface P-selectin by controlling CD63 transfer from endosomes to Weibel-Palade bodies, affecting leukocyte recruitment during inflammation.

DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity

The paper identifies DFG-1 residues as a target for designing selective kinase inhibitors with non-canonical binding modes, showing that bulky DFG-1 residues enable selectivity over smaller ones.