Author

V. Gerke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

J. Goretzko· 2 shared L. Greune· 2 shared S. Schloer· 2 shared T. Zobel· 2 shared U. Rescher· 2 shared A. L. Linard Matos· 1 shared A. Mecate-Zambrano· 1 shared B. E. Michels· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

J. Goretzko

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Early endosomes act as local exocytosis hubs to repair endothelial membrane damage

N. Raj, L. Greune, M. Kahms, K. Mildner, R. Franzkoch, O. E. Psathaki, T. Zobel, D. Zeuschner, J. Klingauf, V. Gerke

The paper shows early endosomes release membrane material via Ca2+-induced exocytosis to repair endothelial cell membrane damage.

bioRxiv · Nov 2, 2022Cell Biology

Human endothelial cells display a rapid and fluid flow dependent tensional stress increase in response to tumor necrosis factor-α

M. Brandt, V. Gerke, T. Betz

This study shows that TNF-α rapidly increases mechanical tension in human endothelial cells within 4 minutes, which can be reversed by shear flow.

bioRxiv · Jan 12, 2022Biophysics

Leukocyte adhesion is governed by endolysosomal two pore channel 2 (TPC2)

J. Goretzko, N. Heitzig, K. Thomas, E. K. Krogsaeter, J. Nass, A. L. Linard Matos, T. Wegner, S. Schloer, V. Gerke, J. Rossaint, F. Glorius, F. Bracher, C. M. Grimm, U. Rescher

The paper shows that TPC2 regulates endothelial cell surface P-selectin by controlling CD63 transfer from endosomes to Weibel-Palade bodies, affecting leukocyte recruitment during inflammation.

bioRxiv · Sep 28, 2021 · PreprintImmunology

A novel adhesive complex at the base of intestinal microvilli

C. Hartmann, E.-M. Thuering, B. E. Michels, D. Pajonczyk, S. Leussink, L. Greune, F. Brinkmann, M. Glaesner-Ebnet, E. Wardelmann, T. Zobel, M. A. Schmidt, V. Gerke, K. T. Ebnet

The paper identifies a novel adhesive complex at the base of intestinal microvilli composed of TMIGD1, EBP50, and ezrin, and describes its regulation by phosphorylation and phosphatase activity.

bioRxiv · Jan 25, 2021 · PreprintCell Biology

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

S. Schloer, L. Brunotte, J. Goretzko, A. Mecate-Zambrano, N. Korthals, V. Gerke, S. Ludwig, U. Rescher

This study identifies fluoxetine and other FIASMAs as inhibitors of SARS-CoV-2 entry by targeting endolysosomal acidification and cholesterol accumulation.

Emerging Microbes & Infections · Oct 17, 2020Peer-reviewedMicrobiology