Author

F. Gude

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1

Frequent Co-Authors

J. Froese· 2 shared K. Ehring· 2 shared K. Grobe· 2 shared D. Manikowski· 1 shared J. Goretzko· 1 shared J. Puschmann· 1 shared P. Jakobs· 1 shared S. F. Ehlers· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

J. Froese

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2 papers

Recent·Most cited

Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

K. Ehring, S. F. Ehlers, J. Froese, F. Gude, J. Puschmann, K. Grobe

This study shows that Dispatched (Disp) mediates the shedding and transfer of cholesterol-modified Sonic hedgehog (Shh) to high-density lipoproteins (HDL), with HDL-associated Shh being highly bioactive.

bioRxiv · Feb 8, 2023Cell Biology

Conserved cholesterol-related activities of Dispatched drive Sonic hedgehog shedding from the cell membrane

K. Grobe, K. Ehring, D. Manikowski, J. Froese, P. Jakobs, F. Gude, U. Rescher, J. Goretzko

This study shows that Dispatched (Disp) facilitates cholesterol-dependent ectodomain shedding of Sonic hedgehog (Shh) ligand, and that this process is rescued by cholesterol removal or overexpression of Disp or Patched.

bioRxiv · Oct 19, 2020Cell Biology