Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers
M. de Boer, G. Gouridis, R. Vietrov, S. L. Begg, G. K. Schuurman-Wolters, F. Husada, N. Eleftheriadis, B. Poolman, C. A. McDevitt, T. Cordes
This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.
bioRxiv · Jan 31, 2019Biophysics