C. A. McDevitt

Host subversion of bacterial metallophore usage drives copper intoxication

This paper shows that host use of metallophores to secrete copper intoxicates Staphylococcus aureus during infection.

The two-component regulator WalKR provides an essential link between cell wall homeostasis with DNA replication in Staphylococcus aureus

This study identifies the WalKR two-component system in Staphylococcus aureus as a polyfunctional regulator linking cell wall homeostasis with DNA replication and other essential processes.

The molecular basis of Acinetobacter baumannii cadmium toxicity and resistance

This study identifies CzcE and the CzcCBA efflux system as key factors in A. baumannii's resistance to cadmium stress and reveals metal ion homeostasis changes under cadmium exposure.

Experimental Evolution in vivo to Identify Selective Pressures During Pneumococcal Colonization

This study uses experimental evolution in mice to identify genetic adaptations of Streptococcus pneumoniae during nasal colonization and reveals fitness trade-offs in different host niches.

Conformational and dynamical plasticity in substrate-binding proteins underlies selective transport in ABC importers

This study investigates how substrate-binding proteins (SBPs) in ABC importers change conformation and dynamics in response to different ligands, revealing that transport specificity arises from conformational plasticity rather than a unique closed conformation.

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.